Identification of estrogen-induced genes downregulated by AhR agonists in MCF-7 breast cancer cells using suppression subtractive hybridization.Īryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane (DIM).ĭalessandri KM, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LF. Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium. Cytostatic and antiestrogenic effects of 2-(indol-3-ylmethyl)-3,3'-diindolylmethane, a major in vivo product of dietary indole-3-carbinol.Ĭhen DZ, Qi M, Auborn KJ, Carter TH. However, there is no evidence that it actually works.Ĭhang YC, Riby J, Chang GH, Peng BC, Firestone G, Bjeldanes LF. 29,30Īccording to some manufacturers, DIM can enhanceĮnhance sports performance. These includeĬervical dysplasia and respiratory papillomatosis. Highly preliminary evidence hints that DIM may offer benefit for diseases caused by human papilloma virus (HPV). 28Īgain, on some websites this effect has been over-optimistically termed “balancing testosterone levels.” The overall effect is far too complex and poorly understood to be described as “balancing estrogen in the body,” which is what many websites say about DIM.ĭIM also appears to have an anti-testosterone effect, which could make it helpful for preventing or treating breast cancer. In addition, DIN blocks certain effects of estrogen on cells however, it may enhance other effects of estrogen. 20-27ĭIM appears to alter liver function in such a manner that an increased amount of estrogen becomes metabolized into inactive forms. Some of DIM’s apparent anticancer benefits appear to derive from its complex interactions with estrogen. As with many proposed cancer-preventing substances, there are also circumstances in which DIM might actually increase the risk of cancer. However, this evidence is far too preliminary to serve as the basis for recommending that anyone use DIM. Animal studies hint that DIM is might help prevent various types of cancer, especially breast, cervical, prostate, and uterine cancer.
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